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| Product Name: |
Irbesartan
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| Related proudcts |
raw material, api, |
| Specifications |
USP |
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| Irbesartan is a nonpeptide angiotensin II antagonist that selectively blocks the binding of angiotensin II to the AT1 receptor. In the renin-angiotensin system, angiotensin I is converted by angiotensin-converting enzyme (ACE) to form angiotensin II. Angiotensin II stimulates the adrenal cortex to synthesize and secrete aldosterone, which decreases the excretion of sodium and increases the excretion of potassium. Angiotensin II also acts as a vasoconstrictor in vascular smooth muscle. Irbesartan, by blocking the binding of angiotensin II to the AT1 receptor, promotes vasodilation and decreases the effects of aldosterone. The negative feedback regulation of angiotensin II on renin secretion also is inhibited, but the resulting rise in plasma renin concentrations and consequent rise in angiotensin II plasma concentrations do not counteract the blood pressure¨Clowering effect that occurs. |
| Company: |
Zhongbao Chemicals Co.,Ltd
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| Contact: |
Ms. Erica Yang |
| Address: |
Zhenhua Rd 206 |
| Postcode: |
310030 |
| Tel: |
86 571 87357772 |
| Fax: |
86 571 87357766 |
| E-mail: |
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